Otoferlin abcam

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WebJun 20, 2010 · We propose that otoferlin is involved in replenishing ... mouse antibody to calbindin (Swant, 1:500), mouse antibody to otoferlin (N terminal, Abcam, 1:500), rabbit … WebOct 4, 2010 · Subsequent immunoblots against otoferlin used a monoclonal anti-otoferlin provided by S. Safieddine (Université Pierre et Marie Curie, Paris, France). For otoferlin …

Otoferlin Depletion Results in Abnormal Synaptic Ribbons and …

WebNov 16, 2024 · DAPI is a dye for staining nuclei, N-terminal and C-terminal otoferlin are immunostained by antibodies of anti N-terminal and C-terminal otoferlin (ab53233, … WebNov 7, 2016 · otoferlin and shows that this is mediated via the tail-anchored protein insertion pathway TRC40 (Vogl et al, 2016). The primary otoferlin defect in hearing-impaired … ird hamilton address

Article Function coupling of otoferlin with GAD65 acts to modulate

WebAnti-Otoferlin Antibody Products from Abcam. Anti-Otoferlin antibodies are available from several suppliers. In humans, this protein is encoded by the gene OTOF. The protein may … WebMay 1, 2024 · Otoferlin has also been suggested to have a role in vesicle clathrin-dependent endocytosis, based on its interaction with the AP-2 adaptor protein complex (Duncker et … WebStructurally, otoferlin is a large (∼230 kDa) tail-anchored protein consisting of multiple C2 domains (C2A–C2F), a FerA domain, and a single-pass transmembrane domain (TMD) at … ird gst phone

Otoferlin is a calcium sensor that directly regulates SNARE …

WebMar 21, 2024 · OTOF (Otoferlin) is a Protein Coding gene. Diseases associated with OTOF include Deafness, Autosomal Recessive 9 and Otof-Related Deafness.Among its related … WebJun 4, 2024 · Utricles are vestibular sense organs that encode linear head movements. They are composed of a sensory epithelium with type I and type II hair cells and supporting … ird gst invoice basisWebNov 26, 2024 · synaptic vesicles. Together with the ﬁnding of otoferlin immunoreactivity on endosomal vesicular structures, it was concluded that otoferlin is involved in the reformation of synaptic vesicles from bulk endosomes [13]. This is in agreement with the ﬁnding that otoferlin interacts with the clathrin adaptor protein AP2 [15,16]. ird hardship application nz

"WebOct 20, 2006 · The otoferlin C2D domain contains five-aspartic acid residues that are conserved throughout vertebrate species (Figure S3 A) and are predicted to bind Ca 2+ … " - Otoferlin abcam

Otoferlin abcam

Anti-Otoferlin antibody [13A9] (ab53233) Abcam

Web购买Otoferlin小鼠单克隆抗体[13A9](ab53233)，Otoferlin抗体经Flow Cyt验证，可与人,小鼠样本反应。 ... Abcam is leading the way in addressing this with our range of … WebAbcam - antibodies and reagents supplier, find any antibody Hello. We're improving abcam.com and we'd welcome your ... Mouse monoclonal [13A9] to Otoferlin. Application: …

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WebOct 17, 2006 · A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function … WebJul 25, 2024 · Furthermore, otoferlin was found capable of interacting with multiple SNARE and Cav1.3 proteins simultaneously, forming a heterooligomer complex. We also found …

WebJun 29, 2024 · In mice, loss of otoferlin results in profound hearing loss, and in humans, mutations in otoferlin are responsible for DFNB9, which accounts for 2–8% of congenital …

WebAbcam otoferlin Otoferlin, supplied by Abcam, used in various techniques. Bioz Stars score: 99/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol … Web上海易汇生物科技有限公司，是一家集研发、销售为一体的高新技术生物企业，公司专注于生命科学和生物技术领域，专业提供分子生物学、免疫学、生命科学基础研究以及临床检测 …

WebOtoferlin homologous proteins in humans that have been shown to be associated with human diseases are dysferlin and myoferlin. Both dysferlin and myoferlin have seven C2 …

WebJul 10, 2024 · Sensory hair cells rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the ... were equilibrated in PBS, pH 7.5, and conjugated to 1 μg of anti-GFP antibody … ird hardship applicationWebOct 3, 2024 · The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and depending on the species, mild to strong … ird hardship form nzWebNational Center for Biotechnology Information ird hamiltonWebSections were then incubated for 48 h at 48C between otoferlin and Ca2+ channels. Clearly, further study is with anti-GAD 65 (1:500, SYSY 198102) and anti-otoferlin (1:200, needed to elucidate the mechanistic and functional interrelation- Abcam ab53233). ird hamilton nzWebOct 7, 2024 · A Natural History Study in Individuals With Otoferlin Gene-mediated Hearing Loss. Actual Study Start Date : July 14, 2024. Estimated Primary Completion Date : … order flowers montrealWebDec 27, 2015 · Otoferlin also shows trans-Golgi to PM cycling, with very low levels of PM otoferlin suggesting either brief PM residence, or rare incorporation of otoferlin … order flowers mississaugaWebMar 30, 2011 · Cochlear inner hair cells (IHCs) use Ca2+-dependent exocytosis of glutamate to signal sound information. Otoferlin (Otof), a C2 domain protein essential for IHC … ird hardship nz